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AL-LAD is an alkenated/alkylenated analogue of (6-nor-) LSD, Al lad ‘homolog’ of DMT, that has a slightly lower potency in practice and somewhat shorter duration of effects than LSD although it showed higher potency in theory. Buy Al-LAD blotters paper Online USA
Again, It gained recognition after Alexander Shulgin described the substance in the book TIHKAL. Also, David Nichols and Albert Hofmann described AL-LAD 12 years before that in an article. However, until recently, AL-LAD has not been known to have been available on the market. Buy Al- LAD blotters paper Online USA
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More, Because it is not an alkyl analog it bypasses UK drug analog laws. Moreover, In this early stage of availability on the market. AL-LAD for sale is quickly gaining popularity, having a lot of the virtues of LSD and even advantages over it.
Also, although opinions and reactions always vary as per YMMV. Buy AL-LAD blotters Papers In 2013, N6-allyl-6-norlysergic acid diethylamide (AL-LAD) and (2’S,4’S)-lysergic acid 2,4-dimethylazetidide (LSZ) have appeared on the ‘research chemicals’ / new psychoactive substances (NPS) market in both powdered and blotter form.
Lysergic acid diethylamide (LSD, ) is perhaps one of the most intriguing psychoactive substances known, given how strongly it has impacted scientific and cultural events. The psychoactive properties of LSD were discovered serendipitously by Dr. Albert Hofmann in 1943.
Subsequently, numerous structural modifications of the prototypical lysergamide scaffold have been explored forming the basis for investigations into the nature of the receptor binding and functional activity of LSD. In some cases, information about the effects of several lysergamides in humans is available.
In 2013, N6 -allyl-6-not lysergic acid diethylamide (AL-LAD) and (2’S,4’S)-lysergic acid 2,4-dimethylacetamide (LSZ) appeared on the ‘research chemicals’/new psychoactive substances (NPS) market in both powdered and blotter form.
This study reports the analytical characterization of powdered AL-LAD and LSZ tartrate samples and their semi-quantitative determination on blotter paper.
Included in this study were the use of nuclear magnetic resonance (NMR) spectroscopy, gas chromatography-mass spectrometry (GC-MS), low and high mass accuracy electrospray MS(/MS), high-performance liquid chromatography diode array detection and GC solid-state infrared analysis.
One feature shared by serotonergic psychedelics, such as LSD, is the ability to mediate behavioural responses via the activation of 5-HT2A receptors. Both AL-LAD and LSZ displayed LSD-like responses in male C57BL/6 J mice when employing the head-twitch response (HTR) assay.
AL-LAD and LSZ produced nearly identical inverted-U-shaped dose-dependent effects, with the maximal responses occurring at 200 µg/kg. Analysis of the dose responses by nonlinear regression confirmed that LSZ (ED50 = 114.2 nmol/kg) was equipotent to LSD (ED50 = 132.8 nmol/kg) in mice, whereas AL-LAD was slightly less potent (ED50 = 174.9 nmol/kg).
The extent to which comparison in potency can be translated directly to humans requires further investigation. Chemical and pharmacological data obtained from NPS may assist research communities that are interested in various aspects related to substance use and forensic identification.
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